Radiation-induced genomic instability and bystander effects: implications for radiation protection
نویسندگان
چکیده
منابع مشابه
Radiation-induced genomic instability and bystander effects: implications for radiation protection\*
Evidence has emerged over the past decade for the existence of two cellular phenomenons which challenge the standard paradigms for the induction of biological effects by ionizing radiation. In bnth cases, important genetic changes arke in cells that in themselves receive no radiation exposure. In the first, radiation induces a type of transmissible genomic instability in cells that leads to a p...
متن کاملGenomic Instability and Bystander Effect – Implications for Radiation Protection
The main results of the EC project ‘Genomic instability and radiation-induced cancer’ (RADINSTAB) are reviewed and the potential implications of genomic instability and bystander effect for risk assessment and radiation protection discussed. A basic paradigm in radiobiology is that, after exposure to ionising radiation, the deposition of energy in the cell nucleus and the resulting damage to DN...
متن کاملBystander effects in radiation-induced genomic instability.
Exposure of GM10115 hamster-human hybrid cells to X-rays can result in the induction of chromosomal instability in the progeny of surviving cells. This instability manifests as the dynamic production of novel sub-populations of cells with unique cytogenetic rearrangements involving the "marker" human chromosome. We have used the comet assay to investigate whether there was an elevated level of ...
متن کاملRadiation Induced Bystander Effect
Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects. Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent years. RIBE occurs in unexposed cells which are related to adjacent or distant irradiated cells. RIBE contradict with "target theory" which necessitates radiation tr...
متن کاملRadiation Bystander Effects Mechanism
Introduction: Radiation Induced Bystander Effect (RIBE) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. What is the mechanism of this phenomenon? To have a better understanding of this rather ambiguous concept substantial number of original ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radioprotection
سال: 2002
ISSN: 0033-8451
DOI: 10.1051/radiopro:2002007